Barbara Summers

American Journal of Physiology - Lung Cellular and Molecular Physiology 10.1152/ajplung.00209.2024 Post-print Animals, Pulmonary Disease, Chronic Obstructive, Tertiary Lymphoid Structures, Mice, Lung, Lectins, C-Type, Pulmonary Emphysema, Humans, Autoantibodies, Disease Models, Animal, Phenotype, Mice, Inbred C57BL, Autoimmune Diseases, Male, Mice, Knockout, Female, autoimmunity, COPD, emphysema, lymphatic vasculature, tertiary lymphoid organs yes Summers, Barbara; Kim, Kihwan; Trivedi,...

1 INTRODUCTION During summer 2023, Europe saw record-breaking temperatures across several countries, with the names Cerberus and Charon (Caronte) being given to these events in the media (BBC, 2023). As severe heat events are expected to continue to increase in frequency across Europe as a result of climate change (Bednar-Friedl et al., 2022), effective communication about heatwave risk and the steps members of the public can take to reduce their risk of harm is of considerable importance.

We have previously shown that mice with loss of C-type lectin-like type II (CLEC2), which have lymphatic dysfunction due to the role of CLEC2 in platelets for maintaining separation between the venous and lymphatic system, develop lung tertiary lymphoid organ (TLO) formation and lung injury that resembles an emphysema phenotype of chronic obstructive pulmonary disease (COPD).