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F-NEO-BRIGHT: feasibility and safety of intranasal fresh breast milk in neonatal encephalopathy
Abstract Hypoxic-ischemic encephalopathy (HIE) remains a major cause of neonatal mortality and long-term neurodevelopmental disability. Intranasally delivered mesenchymal stem cells and neurotrophic factors from breast milk have been detected in the central nervous system and may have a role in neuroregenerative processes.
End‐Tidal Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Hypoxic‐Ischemic Encephalopathy
1 Introduction To date only therapeutic hypothermia (TH) has been proven to reduce the risk of death and unfavorable neurological outcomes in infants with moderate-severe hypoxic-ischemic encephalopathy (HIE), which is one of the leading causes of neonatal morbidity and mortality, affecting approximately 1–4 cases in 1000 live births in high-resource settings [1, 2].
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