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Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS

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By Vitaly Zimyanin, Julia Japtok, Aaron Held, Barbara Szewcyk
| tu-dresden.de
Mutations in the Fused in Sarcoma (FUS) gene cause familial amyotrophic lateral sclerosis (ALS), characterized by selective degeneration of spinal motor neurons (sMNs) with relative sparing of cortical neurons (CNs). The mechanisms underlying this cell-type vulnerability remain unclear. Here, we compare CNs and sMNs derived from FUS-ALS models to assess differential responses to FUS mutations.
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