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Barbara Teodoro-Castro on Muck Rack

Barbara Teodoro-Castro

As seen in: BioRxiv, Dialnet - Universidad de La Rioja
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Articles

A toxic STING-SAMHD1 axis drives replication stress in progeria and cancer cells

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By Barbara Teodoro-Castro, Elena V. Shashkova, Atika Malique
| Dialnet - Universidad de La Rioja
STING is an innate immune adaptor, classically activated by cytosolic DNA via cGAS-cGAMP to induce interferon signaling. Recent studies reveal that STING participates in non-canonical signaling pathways and localizes to the nucleus, where its functions remain poorly understood. In Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disease caused by expression of the lamin-A mutant protein ‘progerin’, STING accumulates in the nucleus and drives chronic inflammation.
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A non-canonical cGAS-STING pathway drives cellular and organismal aging

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By Lilian Pereira Silva, Barbara Teodoro-Castro, Kyle S. McCommis, Elena V. Shashkova
| BioRxiv
Abstract Accumulation of cytosolic DNA has emerged as a hallmark of aging, inducing sterile inflammation. STING (Stimulator of Interferon Genes) protein translates the sensing of cytosolic DNA by cGAS (cyclic-GMP-AMP synthase) into an inflammatory response. However, the molecular mechanisms whereby cytosolic DNA-induced cGAS-STING pathway leads to aging remain poorly understood.
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