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Barbara Uzonyi on Muck Rack

Barbara Uzonyi

As seen in: Nature
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Articles

Human factor H-related protein 5 modulates the classical and lectin complement pathways on selected host ligands

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By Hani Hammad, Alexandra T. Matola, Dávid Szakács, Ádám I. Csincsi, Anna M. Blom, Peter N. Gal, Mihály Józsi, Alexandra Papp, Dániel Bencze, Gábor Pál, Barbara Uzonyi
| Nature Verified
Abstract C4b-binding protein (C4BP) and factor H (FH) are the main soluble negative regulators of the classical/lectin (CP/LP) and alternative (AP) complement pathways, respectively. They do not only act in solution but also interact with host ligands such as C-reactive protein (CRP) and extracellular matrix proteins to control complement activation on surfaces.
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