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Barbara Waddell on Muck Rack

Barbara Waddell

As seen in: Emerging Infectious Diseases, Nature, Gut Journal, Thorax
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Articles

Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infections

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By Hannah Betts Verified, Matthew C. Radey, Samuel Lee, Sarah Morgan, Barbara Waddell, Sara Klee, Michael D Parkins, Rafael Hernandez, Alison F. Feder, Colin Manoil, Pradeep Singh, Sardar Karash, Beth A. Traxler
| Nature Verified
Abstract Antibiotic resistance arising during infections is generally thought to be due to mutations in pathogen genomes. Here we studied Pseudomonas aeruginosa and Achromobacter collected from people with cystic fibrosis and non-cystic fibrosis bronchiectasis that suddenly developed 10,000-fold increases in tobramycin resistance after tobramycin treatment was initiated. Genomic analysis showed that resistance did not arise from mutation accumulation or strain displacement.
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Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients

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By Christina S. Thornton, Barbara Waddell, Stephen E. Congly, Julianna Svishchuk
| Gut Journal Verified
Discussion Chronic HEV infection in SOT recipients was first reported in 2008.2 Since that time, infection in many profoundly immune suppressed cohorts have been documented.1 3 HEV is likely under-recognised as many patients are asymptomatic or have non-specific abnormal liver enzyme tests.
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Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients

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By Christina S. Thornton, Barbara Waddell, Stephen E. Congly, Julianna Svishchuk
| Gut Journal Verified
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