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Clinical, Histopathological, and Molecular Characterization of Pediatric MN1 :: ZNF341 -Associated Cancer
1 Introduction The “small round blue cell tumor” morphological pattern is common among pediatric cancers, reflecting their primitive and developmental origins [1]. Despite this apparent uniformity, such neoplasms exhibit diverse clinical presentations, cancer-causing (driver) mutations, and outcomes. Recently, a round-cell tumor with a novel MN1::ZNF341 gene fusion has been described in three children [2].
No evidence of immunosurveillance in mutation-hotspot-driven clonal hematopoiesis
Abstract The theory of immunosurveillance posits that T cells eliminate clones harboring nonself-antigens generated by somatic mutations. Although a role of immunosurveillance in cancer is supported by evidence, whether it affects precancerous expansions has not been well established.
The Sanctuary lädt ein! 15.Juni 2025, 10.00-13:30
The Sanctuary, Fuchsthallergasse 11/29, 1090 WienFuchsthallergasse 11/29 1090 Wien 15. Juni 2025 10.00 - 13:30 Wir laden dich ein, The Sanctuary in all seinen Facetten kennenzulernen – mit offenen Türen, feinem Tee und kleinen Snacks, viel Raum zum Ankommen, zum Erleben unserer Methoden und zum persönlichen Austausch mit dem Team – eine herzliche Gelegenheit, uns, unsere Arbeit und unsere Räume in entspannter Atmosphäre zu entdecken.
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