Barbara Wirthl

ANC assemblies of iron oxide nanocubes SAR specific absorption rate 1 Introduction Hyperthermia therapy is the use of heat to treat cancer, either by destroying tumour cells directly or by making them more susceptible to other treatments, such as radiation therapy or chemotherapy [1]. A temperature above 50 ° C $$ {50}^{{}^{\circ}}\mathrm{C} $$ causes irreparable coagulation of proteins and other biological molecules and can therefore be used to ablate tumour cells [2].

Magnetic nanoparticles have emerged as a promising approach to improving cancer treatment. However, many nanoparticle designs fail in clinical trials due to a lack of understanding of how to overcome the in vivo transport barriers. To address this shortcoming, we develop a computational model aimed at the study of magnetic nanoparticles in vitro and in vivo.

Loading metrics Open Access Peer-reviewed Research Article Barbara Wirthl , Johannes Kremheller , Bernhard A. Schrefler, Wolfgang A. Wall Barbara Wirthl, Johannes Kremheller, Bernhard A. Schrefler, Wolfgang A. Wall Published: February 5, 2020 https://doi.org/10.1371/journal.pone.0228443 Figures Abstract One of the main challenges in increasing the efficacy of conventional chemotherapeutics is the fact that they do not reach cancerous cells at a sufficiently high dosage.