Barbara Xiong

Abstract Spatial omics technologies facilitate comprehensive exploration of tissue microenvironments across development and disease. Yet a theoretical framework for modeling and comparing tissue architecture in diverse biological contexts remains lacking. We introduce N-Orbit, a mathematical model that captures both cell-type composition and spatial relationships within tissue cellular neighborhoods, encoding them as vectors for efficient distance calculations.

Abstract The concept of cellular neighborhoods, defined as recurring structures within the tissue with characteristic cell compositions and interactions, has transformed our understanding of the complexity and dynamics of tumor ecosystems. Recent advances in spatial omics and computational modeling have enabled high-resolution mapping of these neighborhoods, providing unprecedented insights into their roles in shaping tumor heterogeneity, evolution and therapeutic responses.

Spaces can say a lot about a person, but it can also help create a feeling and environment for the users in a space. Stress is inevitable in society today, but there are different ways to help to create a relaxing space that can be soothing and calm. Here are three simple ways to help create a relaxing space that can be use year round. Candles One of the best ways to create a relaxing environment is through the use of smell.