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Barbara Zhao on Muck Rack

Barbara Zhao

As seen in: Nature, BioRxiv
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Articles

Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity

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By Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Kathleen Cook, Sarah Trovillion, Natalia Bottasso-Arias, Simon Han, Samantha Goodwin, Nicholas Russell, Gerald Saunders, Amanda Zacharias, Samantha Brugmann, Jeffrey A. Whitsett, Debora Sinner, Xin Sun, Daniel T. Swarr, William J. Zacharias, Amber Elitz
| Nature Verified
Abstract Mammalian lung development requires coordinated gene regulation to drive lung bud formation, branching morphogenesis, proximal-distal patterning, and epithelial specification. While key transcriptional and signaling regulators are known, the epigenetic regulators are less well studied. Here, we identify the canonical BAF complex as essential for lung epithelial development.
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The homeobox transcription factor Cux1 coordinates postnatal epithelial developmental timing but is dispensable for lung organogenesis and regeneration

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By Sharlene Fernandes, Barbara Zhao, Jacob Socha, Helen Warheit-Niemi
| BioRxiv
Abstract Lung epithelial progenitors use a complex network of known and predicted transcriptional regulators to influence early lung development. Here, we evaluate the function of one predicted regulator, Cux1, that we identified from transcriptional regulatory analysis of the SOX9+ distal lung progenitor network. We generated a new Cux1-floxed mouse model and created an epithelial-specific knockout of Cux1 using Shh-Cre (Cux1ShhCre-LOF).
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