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Bärbel Junge

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Articles

Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling

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By Milena Kalmer, Alessia Piergentili, Mia Mönnig, Chunxiao Zhou, Jonas Goßen, Siddharth Gupta, Laura Schulz, Anna Spitzer, Stefan Tillmann, Kim Kricheldorf, Kristina Pannen, Jacob Piehler, Christian Pecquet, Marcelo A. S. de Toledo, Stefan Constantinescu, Giulia Rossetti, Steffen Koschmieder, Nicolas Chatain, Chiara Wirths, Rebecca Lemanzyk, Bärbel Junge, Joelle Schifflers, Angela Galauner
| Nature Verified
Abstract Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR; MPL), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V617F-driven disease. Here, we hypothesized a distinct role for TYK2 in CALR-mutant driven MPN. We found constitutive TYK2 phosphorylation in CALRdel52/ins5- and MPLW515K- but not JAK2V617F-expressing cells.
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