Barbora Kalousková

Plasma membrane function and organization are mediated by the dynamic and intricate interplay of thousands of different proteins and lipids. Lipids assume diverse roles in plasma membrane organization: As building blocks of the membrane, they provide a matrix for transmembrane proteins and collectively create a membrane environment characterized by, among others, a certain lateral pressure profile, membrane thickness and charge distribution, which can shape protein function.

Microdevice for confinement of (T-)cells on functionalized bio-interfaces Mechanical stimuli are an integral part to the natural cellular microenvironment, influencing cell growth, differentiation, and survival, particularly in mechanically challenging environments like tumors. These stimuli are also crucial in the T-cell microenvironment, where they play a role in antigen recognition and pathogen detection.

Abstract Signaling by the human C-type lectin-like receptor, natural killer (NK) cell inhibitory receptor NKR-P1, has a critical role in many immune-related diseases and cancer. C-type lectin-like receptors have weak affinities to their ligands; therefore, setting up a comprehensive model of NKR-P1-LLT1 interactions that considers the natural state of the receptor on the cell surface is necessary to understand its functions.