Barbora Lemrová
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Synthesis of Imidazo[2,1-a]isoindolones via Rearrangement and Tandem Cyclization of Amino-Acid-Based N-Phenacyl-2-cyano-4-nitrobenzensulfonamides
Introduction Click to copy section linkSection link copied! The Smiles-type rearrangement of substrates containing the combination of electron-poor aromatic rings with alkyl groups activated by adjacent electron-withdrawing functionalities is a simple strategy to create C(sp3)–C(sp2) bonds without the need for metal catalysis. (1,2) Recently, this approach was applied for the synthesis of different heterocyclic scaffolds from various N-substituted nitrobenzenesulfonamides.
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