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Barbora Nemcova

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Articles

Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta‐analysis

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By Katerina Matejkova, Barbora Stastna, Tatana Dolezalova, Barbora Nemcova
| Wiley Online Library Verified
1 INTRODUCTION The MRE11, RAD50, and NBN genes code for the constituents of the nuclear heterotrimeric MRN protein complex sensing DNA double-strand breaks.1 The MRN complex acts as a DNA damage sensor, aids in the selection of DNA repair strategies (facilitating homologous recombination repair) and participates in intracellular responses to DNA damage through multiple protein–protein interactions.2 Carriers of bi-allelic germline pathogenic variants (gPV) develop rare autosomal recessive...
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