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HIF‐1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia
1 INTRODUCTION Adaptation to chronic hypoxia (CH) is known to protect the heart against acute ischemia/reperfusion (I/R) injury. In line with the human epidemiological surveys,1, 2 the vast majority of animal studies demonstrated that CH confers the protective long-lasting phenotype against major endpoints of acute I/R injury (reviewed in3).
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