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Barbora Pravdova on Muck Rack

Barbora Pravdova

As seen in: BioRxiv
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Articles

Limited response of primary nasal epithelial cells to Bordetella pertussis infection and the effector protein BteA

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By Martin Zmuda, Barbora Pravdova, Ivana Malcova, Ondrej Cerny
| BioRxiv
Abstract Bordetella pertussis is a Gram-negative coccobacillus that causes whooping cough or pertussis, a respiratory disease that has recently experienced a resurgence. Upon entering the respiratory tract, B. pertussis colonizes the airway epithelium and attaches to ciliated cells. Here, we used primary human nasal epithelial cells (hNECs) cultured at the air-liquid interface, and investigated their interaction with the B.
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The Bordetella effector protein BteA induces host cell death by disruption of calcium homeostasis

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By Eliska Sedlackova, Martin Zmuda, Barbora Pravdova, Monika Cizkova
| BioRxiv
Abstract Bordetella pertussis is the causative agent of whooping cough in humans, a disease that has recently experienced a resurgence. In contrast, Bordetella bronchiseptica infects the respiratory tract of various mammalian species, causing a range of symptoms from asymptomatic chronic carriage to acute illness. Both pathogens utilize type III secretion system (T3SS) to deliver the effector protein BteA into host cells.
Open in Who Shared Issue with article?
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