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Front Cover: Design of Potent Mannose‐6‐Phosphate Derivatives as Ligands for CI‐M6P/IGF2R Using Fluorescence Polarization Assay
Graphical Abstract High-affinity M6P mimetics. In their Research Article (DOI: 10.1002/chem.202500973), J. Kaminský, K. Parkan, L. Žáková and co-workers report how they designed stable mannose-6-phosphate derivatives and evaluated their binding to CI-M6P/IGF2R by using a fluorescence polarization assay. Multivalent ligands and phosphonate-based mimetics showed enhanced affinity, offering promising tools for targeted lysosomal delivery. Artwork by Tomáš Belloň / IOCB Prague.
Design of potent mannose‐6‐phosphate derivatives as ligands for CI‐M6P/IGF2R using fluorescence polarization assay
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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