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Barbora Výmolová on Muck Rack

Barbora Výmolová

As seen in: Nature
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Articles

FAP + pericyte-like cells promote monocyte differentiation into tumor-associated macrophages in glioblastoma

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By Barbora Výmolová, Nikola Ternerová, Daniel Straka, Zdislava Vanickova, Helena Skalnikova, Michal Kolář, Jan Kubovciak, Eva Balaziova, Petr Výmola, Lisa M Ebert, Ashwini Patil, Robert Tomas, David Netuka, Guillermo Gomez, Magdalena Houdova Megova, Chloe Shard, Tereza Svablova, Tomas Buna, Evzen Krepela, Jana Sachova, Petr Hrabal, Petr Busek, Aleksi Sedo
| Nature Verified
Abstract Glioblastoma (GBM) is a highly aggressive primary brain tumor characterized by profound immunosuppression that facilitates tumor progression and promotes therapeutic resistance. Fibroblast activation protein (FAP), a recognized theranostic target in multiple cancers, is upregulated in GBM and predominantly expressed by pericyte-like stromal cells.
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Molecularly targeted protease-activated probes for visualization of glioblastoma: a comparison with 5-ALA

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By Petr Výmola, Nikola Ternerová, Barbora Výmolová, Elena Garcia-Borja
| Journal of Neurosurgery Verified
Keywords: fluorescence-guided surgery; glioblastoma; 5-ALA; mouse models; activity-based probes; cathepsin; oncology Surgery remains the mainstay of treatment for glioblastoma (GBM), the most malignant and most common primary brain tumor in adults.
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