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Articles

Algorithm to improve the diagnosis of paraneoplastic neurological syndromes associated with SOX1 antibodies

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By Ingo Kleiter, Peter Körtvélyessy, Andrew J. McKeon, Barcelona Autonoma
| Frontiers
Highlights In many clinical laboratories SOX1-abs are determined by commercial line blots without confirmation by cell-based assay (CBA). However, the diagnostic yield of SOX1-abs detected by commercial line blots is low and the accessibility to confirmatory CBA with HEK293 cells expressing SOX1 is limited. For sera which are SOX1-abs positive in the line blot and tissue-based assay (TBA) (44%) confirmation by CBA can be spared.
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