Bardia Karim
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5-Fluorouracil (5-FU)-Induced Organ Toxicities: Mechanisms, Management, and Prevention Strategies
Abstract Fluoropyrimidines are a class of chemotherapy drugs used to treat various solid tumors. 5-Fluorouracil (5-FU) an antimetabolite in the fluoropyrimidine family, which has shown remarkable efficacy against a variety of solid tumors, is a crucial medication in the treatment of cancer. However, severe organ toxicities frequently restrict its therapeutic potential.
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES , , , , , , , , & (2016). Effects of thymoquinone against cisplatin-induced cardiac injury in rats. Acta Cirurgica Brasileira, 31, 271–277. , , , , & (2022). Prevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa in rats. Revista Portuguesa de Cardiologia, 41, 99–105. , & (2013).
5-Flourouracil-induced toxicity in both male and female reproductive systems: A narrative review
Introduction 5-flourouracil (5FU) is a well-known chemotherapeutic agent commonly administered for treating a vast number of solid malignant tumors, including epithelial cell malignancies emerging from the genitourinary and gastrointestinal tracts (especially those of colon, pancreas, and stomach), breast, and also epithelial malignancies found in the head and neck.
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