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Articles

γ-Aminobutyric Acid Is Synthesized and Released by the Endothelium

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By Suvajit Sen, Sohini Roy, Gautam Bandyopadhyay, Bari Scott
| circres.ahajournals.org
Rationale: Gamma aminobutyric acid (GABA), a neurotransmitter of the central nervous system, is found in the systemic circulation of humans at a concentration between 0.5 and 3 μmol/L. However, the potential source of circulating GABA and its significance on the vascular system remains unknown. We hypothesized that endothelial cells (ECs) may synthesize and release GABA to modulate some functions in the EC and after its release into the circulation.
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