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Baris Karakullukcu on Muck Rack

Baris Karakullukcu

As seen in: Nature, Cancer Treatment Reviews, EJSO - European Journal of Surgical Oncology
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Articles

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma - Nature Communications

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By Joris B. W, Joleen J. H, Michiel W. M, Baris Karakullukcu
| Nature Verified
Abstract Surgery for locoregionally advanced head and neck squamous cell carcinoma (HNSCC) results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non-randomized phase Ib/IIa trial, 32 HNSCC patients are treated with 2 doses (in weeks 1 and 3) of immune checkpoint blockade (ICB) using nivolumab (NIVO MONO, n = 6, phase Ib arm A) or nivolumab plus a single dose of ipilimumab (COMBO, n = 26, 6 in phase Ib arm B, and 20 in phase IIa) prior to surgery.
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Contralateral regional recurrence after elective unilateral neck irradiation in oropharyngeal carcinoma: A literature-based critical review

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By Abrahim Al-Mamgani, Erik van Werkhoven, Arash Navran, Baris Karakullukcu
| Cancer Treatment Reviews Verified
Background: The head and neck region has rich regional lymphatic network, with a theoretical risk on contralateral metastasis from oropharyngeal cancer (OPC). There is a long-standing convention to irradiate the great majority of these tumors electively to both sides of the neck to reduce the risk of contralateral regional failure (cRF), but this can induce significant toxicity.
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