Baris Sergi

Characterization of Compounds 1–4 [Cp*Ir(C16H14NO)(PTA)](PF6) (1) L1 (24.9 mg, 0.105 mmol); Et3N (15 μL, 0.108 mmol); [Cp*IrCl2]2 (40.4 mg, 0.0507 mmol); PTA (16.7 mg, 0.106 mmol); NH4PF6 (17.0 mg, 0.104 mmol) were used. Yield: 58 mg, 0.067 mmol, 64%; 1H NMR ((CD3)2CO, 500 MHz, 298 K, δ): 8.06–8.03 (m, 2H, Ar–CH), 7.56 (m, 3H, Ar–CH), 7.49 (app tt, 2H, 3J(1H–1H) = 7.8 Hz, 4J(1H–1H) = 1.4 Hz Ar–CH), 7.28 (tt, 1H, 3J(1H–1H) = 7.5 Hz, 4J(1H–1H) = 1.2 Hz, Ar–CH), 7.21 (br.

Abstract Epigenetic changes drive differential gene expression, contributing to oncogenic transformation and drug resistance. Lysosomes are crucial in cell signaling and the sequestration of toxins and chemotherapeutic agents. This sequestration followed by expulsion through lysosomal exocytosis is a factor in drug resistance. The epigenetic regulation of lysosomal exocytosis remains poorly understood.

Enhanced selectivity towards melanoma cells with zinc(II)-Schiff bases containing imidazole derivatives Zinc(II)-complexes with the general formula [Zn(L)2] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2- methyl-1H-imidazole on 2-position and their respective ligands (HL1 or HL2) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry.