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Diffusion MRI as a potential biomarker for monitoring recovery after surgical repair of traumatic peripheral nerve injuries: a preliminary feasibility longitudinal case series
Abstract After transection, peripheral nerve regeneration requires repair surgery in a timely manner. Unfortunately, up to 40% of peripheral nerve repairs fail to achieve functional recovery. Patients with failed peripheral nerve repairs require additional surgical interventions, but current methods detecting clinical failure offer limited information, resulting in delayed management and suboptimal outcomes.
Impact of tension-free autograft repair on early sensory recovery in polyethylene glycol (PEG)-mediated axonal fusion following traumatic peripheral nerve injuries
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Abstract Autograft repairs remain inferior to primary neurorrhaphy, largely due to axonal regeneration across two coaptation sites. PEG–mediated neurorrhaphy has been shown to enhance recovery following peripheral nerve injury by mitigating Wallerian degeneration. Whether PEG can overcome these limitations in human autografts remains unclear. We therefore compared sensory recovery following PEG-mediated primary versus PEG-mediated autograft neurorrhaphy.
By Ricardo A. Torres-Guzman, Sriya Nemani, Franklin R. Gergoudis, Benjamin Savitz, Anthony Hoang, Hüseyin Karagöz, Yusha Liu, Lesley Wong, Feng Zhang, William Lineaweaver, Brian C. Drolet, J. Bradford Hill, Wesley Thayer, Barite Gutama, Ronald M. Cornely, Douglas R. Weikert, Panambur L. Bhandari, Shady Elmaraghi
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Nature
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