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Barnabás Váradi on Muck Rack

Barnabás Váradi

As seen in: British Pharmacological Society
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Articles

Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib

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By Bence Ágg, Bennet Y. Weber, Gábor B. Brenner, Barnabás Váradi
| British Pharmacological Society
I/R ischaemia/reperfusion COX-2 cyclooxygenase-2 mRNA messenger RNA miRNA microRNA CPM: counts per million TPM transcript per million What is already known? Rofecoxib showed clinical cardiotoxicity in a comorbid patient population during post-marketing observations. The ‘hidden cardiotoxicity’ of rofecoxib was detectable in a preclinical I/R comorbidity model. What does this study add?
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