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Barnes AC

As seen in: Wiley Online Library, University of Oxford
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Articles

β-cell recovery revisited: Is prediabetes remission driven by insulin sensitivity or β-cell function?

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By Joonyub Lee, Kun-Ho Yoon, Barnes AC
| Wiley Online Library Verified
Lee, J. and Yoon, K.-H. (2026), β-cell recovery revisited: Is prediabetes remission driven by insulin sensitivity or β-cell function?. J Diabetes Investig. https://doi.org/10.1111/jdi.70292 The concept of “prediabetes remission”—the reversion from dysglycemia to normoglycemia—has gained substantial attention in recent years.
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Aetiology of Type 2 diabetes in people with a 'normal' body mass index: Testing the Personal Fat Threshold Hypothesis.

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By Irvine KM, Barnes AC, Solovyova AS, Clark LG
| University of Oxford
Weight loss in overweight or obese individuals with type 2 diabetes (T2D) can normalize hepatic fat metabolism, decrease fatty acid oversupply to beta cells and restore normoglycaemia. One in six people has BMI <27kg/m2 at diagnosis, and their T2D is assumed to have different aetiology. The Personal Fat Threshold hypothesis postulated differing individual thresholds for lipid overspill and adverse effects on beta cell function.
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