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Cholangiocarcinoma - evolving concepts and therapeutic strategies
Abstract Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features of cholangiocyte differentiation: cholangiocarcinomas are categorized according to anatomical location as intrahepatic (iCCA), perihilar (pCCA), or distal (dCCA). Each subtype has a distinct epidemiology, biology, prognosis, and strategy for clinical management. The incidence of cholangiocarcinoma, particularly iCCA, has increased globally over the past few decades.
Cholangiocarcinoma - evolving concepts and therapeutic strategies
1.Rizvi, S. & Gores, G. J. Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology 145, 1215–1229 (2013).2.Saha, S. K., Zhu, A. X., Fuchs, C. S. & Brooks, G. A. Forty-year trends in cholangiocarcinoma incidence in the US: intrahepatic disease on the rise. Oncologist 21, 594–599 (2016).3.Khan, S. A. et al. Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J. Hepatol. 37, 806–813 (2002).4.Taylor-Robinson, S. D. et al.
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