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Barry A. Schoenike on Muck Rack

Barry A. Schoenike

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Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy

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By John K. Mich, Jennifer Koehler, Itay Raphael, Raphaël Porret, Olivia Hoffman, Anna Patterson, Emily Gohar, Emanuel Coleman, Claudia Espinosa-Garcia, Felipe Paredes, Nicholas H. Varvel, Raymond J. Dingledine, Jamie Maguire, Barry A. Schoenike
| Science Magazine Verified
Editor’s summary Most patients with epilepsy require lifelong medication for seizure management. Hoffman et al. identified Stat3 as a hub gene that regulates transcriptomic changes in the brains of mice after status epilepticus (SE) and in patients with temporal lobe epilepsy. In mice, JAK/STAT signaling was transiently induced during SE and reactivated in the chronic phase weeks after the induction of SE.
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