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Barry Bedell

As seen in: BioRxiv
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Articles

Tau-related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is gradually modulated by β amyloid

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By Felix Carbonell, Carolann McNicoll, Alex Zijdenbos, Barry Bedell
| BioRxiv
Abstract Background: PET imaging studies have shown that spatially distributed measurements of β-amyloid are significantly correlated with glucose metabolism in Mild Cognitive Impairment (MCI) independently of the APOE ε4 genotype. In contrast, the relationship between tau and glucose metabolism at different stages of Alzheimer's Disease (AD) has not been fully understood.
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Spatial association between distributed β-amyloid and tau varies with cognition

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By Felix Carbonell, Alex Zijdenbos, Carolann McNicoll, Barry Bedell
| BioRxiv
Abstract Several PET studies have explored the relationship between β-amyloid load and tau uptake at the early stages of Alzheimer's disease (AD) progression. Most of these studies have focused on the linear relationship between β-amyloid and tau at the local level and their synergistic effect on different AD biomarkers.
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