Barry Connors

Discussion The most surprising result of our study is that EAPs—spikes initiated distal to the AIS—could be readily generated in a large majority (>90%) of sampled PV+ interneurons in two different areas of the neocortex. This is a significantly higher proportion than previously reported. The neocortex has been only sparsely studied; Imbrosci et al. (2015) induced ectopic spikes in only 1 of 24 (∼4%) fast-spiking (presumed PV+) cells in visual neocortex. Elgueta et al.

Abstract Canonically, action potentials of most mammalian neurons initiate at the axon initial segment and propagate bidirectionally: orthodromically along the distal axon, and retrogradely into the soma and dendrites. Under some circumstances action potentials may initiate ectopically, at sites distal to the axon initial segment, and propagate antidromically along the axon.