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Barry DeZonia on Muck Rack

Barry DeZonia

As seen in: ACS Publications, BioRxiv
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Articles

Top–Down Scoring of Spectral Fitness by Image Analysis for Protein Structure Validation

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By Benjamin Harding, Barry DeZonia, Rajat Garg, Ziling Hu
| dx.doi.org
Introduction Click to copy section linkSection link copied! Proteins carry out complex biological functions that are essential to life, and a deeper understanding of protein structures is critical to strengthen our understanding of their mechanisms. NMR spectroscopy offers unparalleled insights into protein structures and dynamics at atomic resolution, providing critical information for understanding biological functions of microcrystalline, (1,2) membrane, (3,4) and fibrous (5) proteins.
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Top-Down Scoring of Spectral Fitness by Image Analysis for Protein Structure Validation

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By Benjamin Harding, Barry DeZonia, Rajat Garg, Ziling Hu
| BioRxiv
Abstract Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for protein structure determination, but traditional approaches require extensive manual assignment of hundreds to thousands of resonances. Here we present NMRFAM-BPHON, a novel "top-down" approach that treats experimental NMR spectra as continuous grayscale images and quantitatively scores the agreement with simulated spectra generated from candidate protein structures.
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OPTO: Automated Optimization for Solid-State NMR Spectroscopy

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By Collin G. Borcik, Thirupathi Ravula, Benjamin Harding, Barry DeZonia
| ACS Publications
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