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Photodynamic priming modulates cellular ATP levels to overcome P‐glycoprotein‐mediated drug efflux in chemoresistant triple‐negative breast cancer
BPD benzoporphyrin derivative BSA bovine serum albumin DMEM Dulbecco's Modified Eagle Medium FBS fetal bovine serum IMDM Iscove's Modified Dulbecco's Medium MDR multidrug resistance OXPHOS oxidative phosphorylation PDP photodynamic priming PDT photodynamic therapy P-gp P-glycoprotein TMRE tetramethyl rhodamine, ethyl ester INTRODUCTION ATP-binding cassette (ABC) transporters comprise a group of membrane proteins found in both prokaryotic and eukaryotic organisms.1 These transporters harness...
Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis
Published In Science Advances Volume 9 | Issue 36 September 2023 Article versions Submission history Received: 19 April 2023 Accepted: 3 August 2023 Permissions See the Reprints and Permissions page for information about permissions for this article. Acknowledgments Funding: This work was supported by NIH grants R01 CA260340 (H.-C.H. and T.H.) and R01 CA256710 (H.-C.H.) and Clark Doctoral Fellows Mid-Career Award (B.J.L.).
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