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Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
eLife assessment This study examines an important aspect of the development of the auditory system, the role of guanine nucleotide-binding protein subunits, GNAIs, in stereociliary bundle formation and orientation, by examining bundle phenotypes in multiple compound GNAI mutants. The experiments are highly rigorous and thorough and include detailed quantifications of bundle morphologies and changes.
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
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