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Barry Scott

As seen in: Nature, betanews, Journal of Pharmacology and Experimental Therapeutics, Information Security Buzz, Daily Business, Northern Review (Ada, OH)
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Articles

Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway

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By Shuke Xiao, Mengjie Wang, Thomas Martin, Barry Scott, Xing Fang, Xinming Liu, Yongjie Yang, Sipei Fu, Steven Truong, Jack F. Gugel, Jennifer Hill, Veronica L. Li, Andrew L. Markhard, Mingming Zhao, Wei Qi, Meng Zhao, Jan Spaas, Wei Wei, Trine Moholdt, John A. Hawley, Christian T. Voldstedlund, Erik Richter, Xiaoke Chen, Katrin J. Svensson, Daniel Bernstein, Leslie Leinwand, Yong Xu, Jonathan Long, Gregory L. Maas, Marcus P. Mullen, Saranya C. Reghupaty
| Nature Verified
Abstract Most mammals consume small and frequent meals. By contrast, pythons are ambush predators that exhibit extreme feeding and fasting patterns and provide a unique model for uncovering molecular mediators of the postprandial response1,2,3. Using untargeted metabolomics, we show that circulating levels of the metabolite para-tyramine-O-sulphate (pTOS) are increased more than 1,000-fold in pythons after a single meal.
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Beyond Exercise and Appetite: The Expanding Biology and Therapeutic Potential of Lac-Phe

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By Mount Allison, Barry Scott, Olaiya Peter Oni
| Journal of Pharmacology and Experimental Therapeutics
Keywords N-lactoyl-phenylalanine Lac-Phe N-lactoyl-amino acids Exerkine Appetite CNDP2 List of non-standard abbreviations ABCC5 (ATP-binding cassette sub-family C member 5) ADIPOQ (Adiponectin gene) AgRP (Agouti-related peptide) AMPK (AMP-activated protein kinase) ARC (Arcuate nucleus) CCK (Cholecystokinin) CEBPα (CCAAT/enhancer-binding protein α) CGRP (Calcitonin gene-related peptide) CNDP2 (Carnosine dipeptidase 2) CPGL (Carboxypeptidase-like protein (CNDP2 gene alias)) CTNNB1 (Catenin...
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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans - Nature Metabolism

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By Barry Scott, Emily Day, John Scanlan, David Finlay Verified
| Nature Verified
Abstract Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies.
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