Barry Willardson

Keywords binding partners, Phosducin, Pdc, G protien College Physical and Mathematical Sciences Department Chemistry and Biochemistry Abstract Cellular signaling is vital to the proper functioning of a cell. In the visual system, as light activates the transmembrane receptor rhodopsin, a series of signals is initiated throughout the cell. This response begins with the activation of G proteins which couple to the rhodopsin. One important player in G protein signaling is Phosducin (Pdc).

Keywords phosducin-like protein, eukaryotic cytosolic chaperonin, G protein coupled receptors, GPCRs College Physical and Mathematical Sciences Department Chemistry and Biochemistry Abstract Eukaryotic cells employ G protein coupled receptors (GPCRs) to detect various extracellular signaling molecules, including many that control cell proliferation.

Keywords PhLP1-Gβ-CCT complex, G protein heterotrimer, Gβγ dimers College Physical and Mathematical Sciences Department Chemistry and Biochemistry Abstract Cells detect and respond to a myriad of extracellular signals via seven-transmembrane G protein-coupled receptors and their associated G protein signaling pathways. The pathway is initiated by the binding of a signaling molecule, such as a hormone or neurotransmitter, to its binding site on the extracellular side of the receptor.