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Barry Young

As seen in: BioRxiv
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Articles

PAN deadenylase ensures proper mitosis under conditions of microtubule stress by regulating spindle integrity and promoting cell survival

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By Jigyasa Verma, Zhengcheng He, Pamela Dean, Barry Young
| BioRxiv
Abstract The Poly(A) Tail Length (PATL) of mRNAs of certain cell-cycle regulatory genes undergo significant trimming during M-phase, however the functional importance is unknown. The Ccr4-Not and PAN complexes account for the majority of cytoplasmic poly(A) deadenylation, however a role in M phase has not been described. We find that under conditions of microtubule stress in yeast, loss of PAN deadenylase activity leads to arrest in M phase, defective spindles, and increased cell death.
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PAN deadenylase is required for mitosis in response to microtubule stress in yeast and humans

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By Jigyasa Verma, Zhengcheng He, Pamela Dean, Barry Young
| BioRxiv
Abstract The Poly(A) Tail Length (PATL) of mRNAs of certain cell-cycle regulatory genes undergo significant trimming during M-phase, however the functional importance is unknown. The Ccr4-Not and PAN complexes account for the majority of cytoplasmic poly(A) deadenylation, but their potential roles in regulation of cell-cycle mRNA PATLs has not been investigated.
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