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TET2, tumor control, and CAR T cell hyperproliferation
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Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP
Barsha Dash, Paul J. Belmonte, Sydney R. Fine, Michael J. Shapiro, Ji Young Chung, Aaron D. Schwab, Shaylene A. McCue, Matthew J. Rajcula and Virginia Smith Shapiro J Immunol July 15, 2019, 203 (2) 408-417; DOI: https://doi.org/10.4049/jimmunol.1801443 Key Points In vivo, T cell maturation entails increasing resistance to complement proteins. In vitro, MBL2 is required for complement deposition on immature thymocytes. NKAP-deficient T cells that fail maturation die by ferroptosis, not by complement.
Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP
Barsha Dash, Paul J. Belmonte, Sydney R. Fine, Michael J. Shapiro, Ji Young Chung, Aaron D. Schwab, Shaylene A. McCue, Matthew J. Rajcula and Virginia Smith Shapiro J Immunol June 7, 2019, ji1801443; DOI: https://doi.org/10.4049/jimmunol.1801443 Key Points In vivo, T cell maturation entails increasing resistance to complement proteins. In vitro, MBL2 is required for complement deposition on immature thymocytes. NKAP-deficient T cells that fail maturation die by ferroptosis, not by complement.
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