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Bart Borghans on Muck Rack

Bart Borghans

As seen in: Nature, BioRxiv
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Articles

Allosteric modulation of proton binding confers Cl- activation and glutamate selectivity to vesicular glutamate transporters

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By Bart Borghans, Daniel Kortzak, Piersilvio Longo, Jan-Philipp Machtens
| BioRxiv
Abstract Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate and remove luminal Cl- via an additional anion channel mode. Both of these transport functions are stimulated by luminal acidification, luminal-positive membrane potential, and luminal Cl-. We studied VGLUT1 transporter/channel activation using a combination of heterologous expression, cellular electrophysiology, fast solution exchange, and mathematical modeling.
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Vesicular glutamate transporters are H+-anion exchangers that operate at variable stoichiometry - Nature Communications

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By Bettina Kolen, Bart Borghans, Daniel Kortzak, Cora Hannack, Raul Guzman, Ghanim Ullah
| Nature Verified
Abstract Vesicular glutamate transporters accumulate glutamate in synaptic vesicles, where they also function as a major Cl- efflux pathway. Here we combine heterologous expression and cellular electrophysiology with mathematical modeling to understand the mechanisms underlying this dual function of rat VGLUT1. When glutamate is the main cytoplasmic anion, VGLUT1 functions as H+-glutamate exchanger, with a transport rate of around 600 s−1 at −160 mV.
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