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Bart Heeg

As seen in: Wiley Online Library, Educational Studies, Future Medicine, European Urology, Value in Health Journal
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Articles

Methods for Evaluation of Surrogate Endpoints for HTA Decision Making: A Good Practices Report of an ISPOR Task Force

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By Bart Heeg
| Value in Health Journal Verified
1Biostatistics Research Group, Division of Public Health and Epidemiology, School of Medicine, University of Leicester, Leicester, UK 2Center for Research on Health and Social Care management, SDA Bocconi School of Management, Milan, Italy 3National Health Care Institute, Diemen, The Netherlands 4Peninsula Technology Assessment Group (PenTAG), University of Exeter, Exeter, UK 5National Institute for Health and Care Excellence, London, UK 6Department of Health Research Methods, Evidence, and...
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Alone, together: On the benefits of Bayesian borrowing in a meta‐analytic setting

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By Ofir Harari, Mohsen Soltanifar, Andre Verhoek, Bart Heeg
| Wiley Online Library Verified
It is common practice to use hierarchical Bayesian model for the informing of a pediatric randomized controlled trial (RCT) by adult data, using a prespecified borrowing fraction parameter (BFP). This implicitly assumes that the BFP is intuitive and corresponds to the degree of similarity between the populations. Generalizing this model to any historical studies, naturally leads to empirical Bayes meta-analysis. In this paper we calculate the Bayesian BFPs and study the factors that drive them.
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Bayesian hierarchical model-based network meta-analysis to overcome survival extrapolation challenges caused by data immaturity

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By Bart Heeg, Gabriel Tremblay, Ofir Harari, Andre Verhoek
| Future Medicine Verified
Journal of Comparative Effectiveness ResearchAhead of Print MethodologyOpen Access Abstract Aim: This research evaluated standard Weibull mixture cure (WMC) network meta-analysis (NMA) with Bayesian hierarchical (BH) WMC NMA to inform long-term survival of therapies. Materials & methods: Four trials in previously treated metastatic non-small-cell lung cancer with PD-L1 >1% were used comparing docetaxel with nivolumab, pembrolizumab and atezolizumab.
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