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Bart J Keulen on Muck Rack

Bart J Keulen

As seen in: Nature, BMJ Open, The Lancet
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Articles

Matters arising: bridging predictive algorithms and clinical practice in DBS contact selection

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By Yarit Wiggerts, Deborah Hubers, Bart J Keulen, Martijn G. J. de Neeling, Mariëlle J. Stam, Bernadette C. M. van Wijk, Maarten Bot, Rick Schuurman, Rob de Bie, Martijn Beudel, Annabel van der Weide
| Nature Verified
arising from Marjolein Muller et al. npj Parkinson’s Disease https://doi.org/10.1038/s41531-025-01092-y (2025) Optimal contact selection is a critical determinant of deep brain stimulation (DBS) outcome in Parkinson’s disease, yet it remains one of the most challenging steps in clinical practice.
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Levodopa-related physiomarkers during deep brain stimulation in Parkinson’s disease

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By Carina R. Oehrn, Mariëlle J. Stam, Bart J Keulen, Deborah Hubers, Rob de Bie, Rick Schuurman, Martijn Beudel, Martijn G. J. de Neeling, Bernadette C. M. van Wijk, Arthur W. G. Buijink
| Nature Verified
Abstract Adaptive deep brain stimulation (aDBS) can adjust stimulation to the (medication) state of patients with Parkinson’s disease using physiological biomarkers (physiomarkers), but whether individuals share a common physiomarker frequency remains unknown. We quantified levodopa-induced spectral changes (2–100 Hz) in local field potential recordings from the subthalamic nucleus during active DBS (median amplitude 2.0 mA, IQR: [1.6, 2.4]) in 52 PD patients (100 hemispheres).
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Adaptive deep brain stimulation in Parkinson's disease

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By Amsterdam Neuroscience, Bart J Keulen, Vrije Universiteit Amsterdam
| The Lancet Verified
Get full text access Log in, subscribe or purchase for full access. References 1. Ben-Shlomo, Y ∙ Darweesh, S ∙ Llibre-Guerra, J ∙ et al. The epidemiology of Parkinson's disease Lancet. 2024; 403:283-292 2. Postuma, RB ∙ Berg, D ∙ Stern, M ∙ et al. MDS clinical diagnostic criteria for Parkinson's disease Mov Disord. 2015; 30:1591-1601 3. Schapira, AHV ∙ Chaudhuri, KR ∙ Jenner, P Non-motor features of Parkinson disease Nat Rev Neurosci. 2017; 18:435-450 4. Poewe, W ∙ Seppi, K ∙ Tanner, CM ∙ et al.
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