Bart Oostenrijk

1 Introduction The biological functions of proteins depend on the amino-acid sequence and the 3D structure, which is stabilized by intramolecular interactions such as van der Waals forces [1]. These noncovalent interactions are critical for protein folding and stability, ultimately determining the functional capacity of proteins. Among these van der Waals bonds, interactions involving sulfur atoms are prevalent in chemical and biological systems [2, 3].