Bart P. Braeckman

1 Introduction Dietary restriction (DR), lowering food intake without causing malnutrition, is the most robust and consistent non-genetic intervention known to improve lifespan and healthspan across a spectrum of organisms ranging from single-celled yeast to primates (Fontana et al. 2010). In the nematode Caenorhabditis elegans, a broad range of DR regimes have been identified, such as bacterial dilution, food deprivation, and eat mutation, which all extend lifespan to varying degrees.