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Bart Smeets

As seen in: Nature, Wiley Online Library, ACS Publications, BioRxiv, Hongkiat, Health Economics Review, Journal of the American Society of Nephrology (JASN)
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Articles

Rigidity transitions in a 3D active foam model of cell monolayers with frictional contact interactions

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By Jef Vangheel, Herman Ramon, Bart Smeets, KU Leuven
| BioRxiv
Abstract In morphogenesis and disease, biological tissues may exhibit diverse mechanical properties due to their capacity to switch between fluid-like to solid-like states through the (un)jamming transition. Here, we introduce a novel foam model to investigate how active mechanical properties and cellular interactions govern this transition in active cell monolayers. This model explicitly represents 3D cell shapes and describes cell-cell interactions via discrete interacting surfaces.
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CCDC158: A novel regulator in renal proximal tubular endocytosis unveiled through exome sequencing and interactome analysis

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By Tjessa Bondue, Bart Smeets, Sergei V. Strelkov, Francesca Cervellini
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors declare no competing interests. Supporting Information Filename Description jcp31447-sup-0001-Supplementary_Figures.pdf1.3 MB Supporting information. jcp31447-sup-0002-Supplementary_Tables.docx163.1 KB Supporting information. jcp31447-sup-0003-Supplementary_Figure_7_Raw_data.pdf88.2 KB Supporting information. jcp31447-sup-0004-Supplementary_Figure_8_Raw_data.pdf204.8 KB Supporting information. REFERENCES , , , , , , , & (2010).
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Emergence of bidirectional cell laning from collective contact guidance - Nature Physics

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By Mathilde Lacroix, Bart Smeets, Carles Blanch-Mercader, Caroline Giuglaris, Jacques Prost
| Nature Verified
Abstract Directed collective cell migration is central to morphogenesis, wound healing and cancer progression. Although the molecular anisotropy of the microenvironment guides this migration, its impact on cell flow patterns remains unexplored. Here we show that subcellular microgrooves elicit a polar mode of collective migration in bidirectional lanes, whose widths reach hundreds of micrometres.
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