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Bart van Lieshout on Muck Rack

Bart van Lieshout

As seen in: Nature, Wiley Online Library
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Articles

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

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By Bart van Lieshout, J. van Hasselt, Aanisah Hanuun
| Wiley Online Library Verified
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? The prediction of clinical efficacy from animal models is essential for the development of anti-tuberculosis (TB) drugs. However, mammalian models are costly, slow, and pose ethical burdens. Zebrafish (Danio rerio) embryos/larvae offer a potential high-throughput, ethical New Approach Methodology (NAM), with a proof of principle for translating the efficacy of isoniazid. WHAT QUESTION DID THIS STUDY ADDRESS?
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Pediatric pharmacokinetics and pharmacodynamics of guanabenz for the treatment of vanishing white matter Original

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By Renate J. Verbeek, Marije M.C. Voermans, Pierre M. Bet, Ron A. A. Mathôt, Dennis van der Laan, Imke H Bartelink, Linda G. Franken, Bart van Lieshout, Joshua Eugenio, Elske van den Berg, Truus E. M. Abbink, Marjo S. van der Knaap
| Nature Verified
Abstract Vanishing White Matter (VWM) is a leukodystrophy with cystic cerebral white matter degeneration, resulting in neurological decline and premature death. There is currently no treatment. Guanabenz, a central α2-adrenergic receptor agonist, ameliorates the disease in VWM mouse models.
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