Bart Verbraeken

Introduction The living cationic ring-opening polymerization (CROP) has long been known to provide wide access to poly(2-oxazoline)s with controlled end-group functionality.(1−9) Substituents on the 2-, 4-, and 5-positions can influence the propagation rates (kp) significantly by electronic and/or steric effects, which govern the reaction (Scheme 1).(10−15) Despite their slow polymerization rates, 2-oxazolines substituted at the sp3-hybridized carbons C4 and C5 can still be of interest as...

Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline) Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this communication, we report the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art polymerization of EtOx in acetonitrile and chlorobenzene.

Poly(2-oxazoline)s and, more recently, also poly(2-oxazine)s represent an emerging class of polymers with a broad range of applications. Surprisingly, to date, the statistical copolymerization of these two cyclic imino ether monomers has not yet been reported. Herein, we demonstrate that the statistical copolymerization of 2-oxazines with 2-oxazolines can lead to the formation of amphiphilic gradient copolymers in a single step.