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Bart Westendorp

As seen in: Science Magazine, BioRxiv
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Articles

A reverse brake for the cell cycle

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By Connor McKenney, Edoardo M. Airoldi, Sunil Kumar Dogga, Bart Westendorp
| Science Magazine Verified
Perspective Cell Biology Mitogenic signaling acts beyond S-phase entry to prevent whole-genome duplications Bart Westendorp b.westendorp@uu.nlAuthors Info & Affiliations Abstract Cancer cells often have abnormal DNA content owing to disruption of the pathways that control the cell cycle. Cells commit to the cell cycle in response to small peptide signals called mitogens, which ensure entry into S phase, when DNA is replicated.
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance.

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By Hendrika A. Segeren, Kathryn Wierenga, Frank M. Riemers, Bart Westendorp
| BioRxiv
Abstract Oncogene-induced replication stress (RS) is a vulnerability of cancer cells that forces reliance on the intra-S-phase checkpoint to ensure faithful genome duplication. Inhibitors of the crucial intra-S-phase checkpoint kinases ATR and CHK1 have been developed, but persistent proliferation and resistance to these drugs remain problematic.
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