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Bartholomew Thomas

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A pilot cohort study of blood brain barrier permeability in Alzheimer’s disease using dynamic contrast enhanced magnetic resonance imaging

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By Aravinthan Varatharaj, Rana S Abadalkareem, Claire Gee, Jessica Teeling, Henrik Zetterberg, Ian Galea, Jay Amin, Steevo Abraham, Bartholomew Thomas, Amy Patricia Kunicki, Angela Darekar
| Nature Verified
Abstract Blood–brain barrier (BBB) dysfunction is implicated as a key link between neuroinflammation and neurodegeneration in Alzheimer’s disease (AD). Peripheral inflammation may exacerbate cognitive decline by promoting BBB breakdown and impairing clearance of amyloid and tau, yet in vivo evidence for this hypothesis remains limited.
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