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Biostimulating fillers and induction of inflammatory pathways: A preclinical investigation of macrophage response to calcium hydroxylapatite and poly‐L lactic acid
1 INTRODUCTION Calcium hydroxylapatite (CaHA, Radiesse®; Merz North America, Raleigh, NC) is a biocompatible, biodegradable, and resorbable biostimulatory filler consisting of calcium hydroxylapatite (CaHA) microspheres (25–45 μm diameter) suspended in a 70% aqueous carboxymethylcellulose gel carrier.
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