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Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson’s disease models
BMC Neuroscience201920:24 https://doi.org/10.1186/s12868-019-0506-8 © The Author(s) 2019 Received: 4 March 2019 Accepted: 15 May 2019 Published: 28 May 2019 Abstract Background Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson’s disease (PD). In several studies it has been shown that in Parkinson’s disease sleep disturbance occurs, which may be the result of a disturbed circadian clock.
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