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Bartosz Gabryelczyk on Muck Rack

Bartosz Gabryelczyk

As seen in: Nature
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Articles

Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

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By Bartosz Gabryelczyk, Ali Miserez, Hao Cai, Xiangyan Shi
| Nature Verified
Abstract Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is involved in both intracellular membraneless organelles and extracellular tissues. Despite growing understanding of LLPS, molecular-level mechanisms behind this process are still not fully established. Here, we use histidine-rich squid beak proteins (HBPs) as model IDPs to shed light on molecular interactions governing LLPS. We show that LLPS of HBPs is mediated though specific modular repeats.
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Time-Resolved Observations of Liquid-Liquid Phase Separation at the Nanoscale Using in Situ Liquid Transmission Electron Microscopy

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By Hortense Le Ferrand, Hao Cai, Martial Duchamp, Bartosz Gabryelczyk
| American Chemical Society
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